Romascano, David Paul RogerBarakovic, MuhamedAuría Rasclosa, AnnaDyrby, Tim B.Thiran, Jean-PhilippeDaducci, Alessandro2017-01-062017-01-062017-01-062017https://infoscience.epfl.ch/handle/20.500.14299/132496Axon Diameter Distributions (ADDs) change during brain development and are altered in several brain pathologies. Mapping ADDs non-invasively using dMRI could provide a useful biomarker, but existing methods are either parametric, orientation dependent, surmmarize the whole ADD as a single measure or use non-standard protocols. We propose to estimate the ADD from an orientation-invariant PGSE protocol optimized for axon diameter sensitivity, using a discrete linear model with smoothness and sparsity regularization. To our knowledge, we are the first to report orientationally invarant ADD estimates from dMRI data.non-parametric ADD mappingmicrostructurediffusion MRItext::conference output::conference proceedings::conference paper