Soshnikova, N.Zechner, D.Huelsken, J.Mishina, Y.Behringer, R. R.Taketo, M. M.Crenshaw, E. B.Birchmeier, W.2008-02-182008-02-182008-02-18200310.1101/gad.263003https://infoscience.epfl.ch/handle/20.500.14299/18787By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling.text::journal::journal article::research article