Viger-Gravel, JasmineAvalos, Claudia E.Kubicki, Dominik J.Gajan, DavidLelli, MorenoOuari, OlivierLesage, AnneEmsley, Lyndon2019-08-012019-08-012019-08-012019-05-2710.1002/anie.201814416https://infoscience.epfl.ch/handle/20.500.14299/159492WOS:000474803100008The introduction of high-frequency, high-power microwave sources, tailored biradicals, and low-temperature magic angle spinning (MAS) probes has led to a rapid development of hyperpolarization strategies for solids and frozen solutions, leading to large gains in NMR sensitivity. Here, we introduce a protocol for efficient hyperpolarization of F-19 nuclei in MAS DNP enhanced NMR spectroscopy. We identified trifluoroethanol-d(3) as a versatile glassy matrix and show that 12mm AMUPol (with microcrystalline KBr) provides direct F-19 DNP enhancements of over 100 at 9.4T. We applied this protocol to obtain DNP-enhanced F-19 and F-19-C-13 cross-polarization (CP) spectra for an active pharmaceutical ingredient and a fluorinated mesostructured hybrid material, using incipient wetness impregnation, with enhancements of approximately 25 and 10 in the bulk solid, respectively. This strategy is a general and straightforward method for obtaining enhanced F-19 MAS spectra from fluorinated materials.Chemistry, MultidisciplinaryChemistryactive pharmaceutical ingredientsdynamic nuclear polarizationmagic angle spinningnmr spectroscopysolid-state nmrmagnetic-resonancepolarizing agentoverhauser-dnphyperpolarizationefficienth-1text::journal::journal article::research article