Bao, XuWang, QianZhu, Jieping2019-02-072019-02-072019-02-07201910.1002/anie.201813356https://infoscience.epfl.ch/handle/20.500.14299/154387Under mild dual photoredox/copper catalysis, the reaction of N-alkoxypyridinium salts with readily available silyl reagents (TMSN3, TMSCN, TMSNCS) afforded d-azido, d-cyano, and d-thiocyanato alcohols in high yields. The reaction went through a domino process involving alkoxy radical generation, 1,5-hydrogen atom transfer (1,5-HAT) and copper-catalyzed functionalization of the resulting C-centered radical. Conditions for catalytic enantioselective d-C(sp3)@H cyanation were also documented.1,5-HATalkoxy radicalC-H activationdual catalysisphotoredox catalysttext::journal::journal article::research article