Trono, Didier2012-04-272012-04-272012-04-27201210.1172/JCI63066https://infoscience.epfl.ch/handle/20.500.14299/79755WOS:000303491400007The use of integrating vectors for gene therapy - required for stable correction of gene expression - carries the risk of insertional mutagenesis, which can lead to activation of a tumorigenic program. In this issue of the JCI, Moiani et al. and Cesana et al. investigate how viral vectors can induce aberrant splicing, resulting in chimeric cellular-viral transcripts. The finding that this is a general phenomenon is concerning, but some of their results do suggest approaches for the development of safeguards in gene therapy vector design.Severe Combined ImmunodeficiencyChronic Granulomatous-DiseaseTransgene ExpressionEndogenous MicrornaLentiviral VectorsIntegrationActivationLineagetext::journal::journal article::research article