Catalytic Enantioselective Michael Addition of α-Aryl-α-Isocyanoacetates to Vinyl Selenone: Synthesis of α,α-Disubstituted α-Amino Acids and (+)- and (−)-Trigonoliimine A

Buyck, ThomasWang, QianZhu, Jieping2013-11-202013-11-202013-11-20201310.1002/anie.201306663https://infoscience.epfl.ch/handle/20.500.14299/97143WOS:000327582900047Be like Mike: The title reaction in the presence of the catalyst 1 afforded Michael adducts in excellent yields and enantioselectivities. The adducts were readily converted into alpha,alpha’-disubstituted alpha-amino acids. The enantioselective total synthesis of both (+)- and (-)-trigonoliimine A was accomplished using one of the Michael adducts derived from this methodology.asymmetric synthesisheterocyclesnatural productsorganocatalysisseleniumCatalytic Enantioselective Michael Addition of α-Aryl-α-Isocyanoacetates to Vinyl Selenone: Synthesis of α,α-Disubstituted α-Amino Acids and (+)- and (−)-Trigonoliimine Atext::journal::journal article::research article