Geissbuehler, MatthiasBonacina, LuigiShcheslavskiy, VladislavBocchio, NoeliaGeissbuehler, StefanLeutenegger, MarcelMärki, IwanWolf, Jean-PierreLasser, Theo2012-03-062012-03-06201210.1021/nl300070nhttps://infoscience.epfl.ch/handle/20.500.14299/78428WOS:000301406800095We present a novel concept for optical spectroscopy called nonlinear correlation spectroscopy (NLCS). NLCS analyses coherent field fluctuations of the second and third harmonic light generated by diffusing nanoparticles. Particles based on noncentrosymmetric nonlinear materials such as KNbO3 show a strong second as well as third harmonic response. The method and the theory are introduced and experimental NLCS results in fetal calf serum are presented showing the promising selectivity of this technique for measurement in complex biological environments.Optical spectroscopyfluorescence correlation spectroscopy (FCS)nonlinear correlation spectroscopy (NLCS)third-harmonic generation (THG)second-harmonic generation (SHG)nonlinear opticstext::journal::journal article::research article