Ordóñez-Morán, PalomaHuelsken, Joerg2012-04-022012-04-022012-04-02201210.1038/emboj.2012.73https://infoscience.epfl.ch/handle/20.500.14299/79143WOS:000303596900002The intestine represents the most vigorously renewing, adult epithelial tissue that makes maintenance of its homeostasis a delicate balance between proliferation, cell cycle arrest, migration, differentiation, and cell death. These processes are precisely controlled by a network of developmental signalling cascades, which include Wnt, Notch, BMP/TGF beta, and Hedgehog pathways. A new, elegant study by Wong et al (2012) now adds Lrig1 as a key player in the control of intestinal homeostasis. As for epidermal stem cells, Lrig1 limits the size of the intestinal progenitor compartment by dampening EGF/ErbB-triggered stem cell expansion.enCancerAlphatext::journal::journal article::review article