Nguyen, Vu Trung TinNguyen, Thanh V. Q.Tran, Trinh T. H.Nguyen, Qui-HienWaser, Jérôme2026-01-152026-01-152026-01-142026-01-1210.1021/jacsau.5c01226https://infoscience.epfl.ch/handle/20.500.14299/258016Csp 3 −Cl bonds are essential as diversification handles in organic synthesis and are found in many natural products and bioactive molecules. In this work, we introduce a general protocol for the selective chlorination of aryl cyclopropanes, olefins, and activated C−H bonds using direct photoexcitation of Willgerodt-type reagents to generate chlorine radicals. Preliminary results for an iodine(I/III) catalytic process starting from abundant chloride salts are also presented. Furthermore, a one-pot protocol has been developed for the telescoped functionalization of benzylic chlorides with C-, NO O-, and S-nucleophiles. Especially, this approach provides a platform to access 1,1-diaryl motifs, which are important building blocks for the synthesis of pharmacophores.enchlorinationcyclopropaneshypervalent iodinedirect excitationphotocatalysistext::journal::journal article::research article