Sache, AntoineReymond, PhilippeBrina, OlivierJung, BerndFarhat, MohamedVargas, Maria Isabel2023-05-222023-05-222023-05-222023-04-1910.1007/s10334-023-01082-2https://infoscience.epfl.ch/handle/20.500.14299/197752WOS:000974278400002ObjectiveWall shear stress (WSS) and its derived spatiotemporal parameters have proven to play a major role on intracranial aneurysms (IAs) growth and rupture. This study aims to demonstrate how ultra-high field (UHF) 7 T phase contrast magnetic resonance imaging (PC-MRI) coupled with advanced image acceleration techniques allows a highly resolved visualization of near-wall hemodynamic parameters patterns in in vitro IAs, paving the way for more robust risk assessment of their growth and rupture.Materials and methodsWe performed pulsatile flow measurements inside three in vitro models of patient-specific IAs using 7 T PC-MRI. To this end, we built an MRI-compatible test bench, which faithfully reproduced a typical physiological intracranial flow rate in the models.ResultsThe ultra-high field 7 T images revealed WSS patterns with high spatiotemporal resolution. Interestingly, the high oscillatory shear index values were found in the core of low WSS vortical structures and in flow stream intersecting regions. In contrast, maxima of WSS occurred around the impinging jet sites.ConclusionsWe showed that the elevated signal-to-noise ratio arising from 7 T PC-MRI enabled to resolve high and low WSS patterns with a high degree of detail.Radiology, Nuclear Medicine & Medical Imagingintracranial aneurysms7 t phase contrast mrihemodynamicswall shear stressin vitro modelsphase-contrast mri4-dimensional flow mrishear-stressnoise ratioblood-flowimage qualitytimevelocityfluidvisualizationtext::journal::journal article::research article