Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity

Wang, Zhe-MingLashuel, Hilal A.2012-09-212012-09-212012-09-21201210.1002/anie.201206561https://infoscience.epfl.ch/handle/20.500.14299/85622WOS:000312942900007Aggravating aggregation: an N-terminal domain that is in close proximity to the polyQ domain in the huntingtin protein, htt105-138, is shown to be highly aggregation prone. Potential cross-talk between this domain and the polyQ region may play a central role in regulating the aggregation and toxicity of Htt-N-terminal fragments.Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicitytext::journal::journal article::research article