Favre, SylvainGerber-Lemaire, SandrineVogel, Pierre2008-05-202008-05-202008-05-20200810.2533/chimia.2008.221https://infoscience.epfl.ch/handle/20.500.14299/25849WOS:000255973000008The development of efficient routes to multi gram quantities of chiral synthons is a key issue in total synthesis of natural products and analogues. The conformationally defined and rigid 8-oxabicyclo[3.2.1]oct-6-en-3-one template appears as an appealing starting material for the development of non iterative approaches to polyoxygenated fragments that are found in a large variety of biologically relevant natural compounds. Desymmetrization and resolution procedures, stereoselective functionalizations and double-chain elongations represent attractive strategies for such synthetic challenges.[4+3]-cycloadditionfuran derivatives2-oxyallyl cationspolyketidestwo-direction chain elongation.text::journal::journal article::research article