Diesel, JFinogenova, AMCramer, N2018-11-082018-11-082018-11-08201810.1021/jacs.8b01181https://infoscience.epfl.ch/handle/20.500.14299/150654WOS:000429508600007Annulated pyridones are an importantscaffold found in many biologically active compounds. ANi(0)-catalyzed C−H functionalization of 2- and 4-pyridones is disclosed, providing access to annulatedpyridones via enantioselective intramolecular olefin hydro-arylation. Key to the success of the transformation was thedevelopment of a sterically hindered and tunableN-heterocyclic carbene ligand resembling a chiral version ofIPr. This ligand allows for mild reaction temperatures, andleads to the annulated pyridones in excellent yields andenantioselectivities.text::journal::journal article::research article