Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry

Guichard, PaulHachet, VirginieMajubu, NorbertNeves, AitanaDemurtas, DavideOlieric, NatachaFluckiger, IsabelleYamada, AkinoriKihara, KumikoNishida, YuichiroMoriya, ShigeharuSteinmetz, Michel O.Hongoh, YuichiGönczy, Pierre2013-08-132013-08-132013-08-13201310.1016/j.cub.2013.06.061https://infoscience.epfl.ch/handle/20.500.14299/94115WOS:000330098200030Centrioles are cylindrical microtubule-based structures whose assembly is critical for the formation of cilia, flagella, and centrosomes. The centriole proximal region harbors a cartwheel that dictates the 9-fold symmetry of centrioles. Although the cartwheel architecture has been recently analyzed, how it connects to the peripheral microtubules is not understood. More generally, a high-resolution view of the proximal region of the centriole is lacking, thus limiting understanding of the underlying assembly mechanisms.Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetrytext::journal::journal article::research article