Montoliu, IvanScherer, MaxBeguelin, FionaDasilva, LaeticiaMari, DanielaSalvioli, StefanoMartin, Franois-Pierre J.Capri, MiriamBucci, LauraOstan, RitaGaragnani, PaoloMonti, DanielaBiagi, ElenaBrigidi, PatriziaKussmann, MartinRezzi, SergeFranceschi, ClaudioCollino, Sebastiano2014-04-022014-04-022014-04-02201410.18632/aging.100630https://infoscience.epfl.ch/handle/20.500.14299/102495WOS:000330826600005As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot-gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.Healthy Agingmetabolomicslipidomicsbiomarkersinflammageingtext::journal::journal article::research article