Synthesis of polycyclic aminal heterocycles via decarboxylative cyclisation of dipeptide derivatives

Robert, Emma G. L.Le Du, EliottWaser, Jerome2022-03-142022-03-142022-03-142022-02-1510.1039/d2cc00167ehttps://infoscience.epfl.ch/handle/20.500.14299/186253WOS:000760162100001An oxidative-decarboxylative intramolecular cyclisation of dipeptide derivatives is reported. This transformation is promoted by phenyl iodine(iii) diacetate (PIDA) in combination with BF3 center dot OEt2. The reaction gives access to a variety of valuable polycyclic N-heterocyclic scaffolds containing 5-, 6-, or 7-membered rings.Chemistry, MultidisciplinaryChemistryn-acyliminium ionsacidsalkaloidsSynthesis of polycyclic aminal heterocycles via decarboxylative cyclisation of dipeptide derivativestext::journal::journal article::research article