Kolchinsky, ArtemyVan Den Heuve, MartijnGriffa, AlessandraHagmann, PatricRocha, Luis M.Sporne, OlafGoni, Joaquin2015-02-202015-02-202015-02-20201410.3389/fninf.2014.00066https://infoscience.epfl.ch/handle/20.500.14299/111583WOS:000348113800001The human brain displays heterogeneous organization in both structure and function. Here we develop a method to characterize brain regions and networks in terms of information-theoretic measures. We look at how these measures scale when larger spatial regions as well as larger connectome sub-networks are considered. This framework is applied to human brain fMRI recordings of resting-state activity and DSI-inferred structural connectivity. We find that strong functional coupling across large spatial distances distinguishes functional hubs from unimodal low-level areas, and that this long-range functional coupling correlates with structural long-range efficiency on the connectome. We also find a set of connectome regions that are both internally integrated and coupled to the rest of the brain, and which resemble previously reported resting-state networks. Finally, we argue that information-theoretic measures are useful for characterizing the functional organization of the brain at multiple scales.human connectomeresting-stateintegrative regionsinformation theorymultivariate mutual informationcomplexity measurestext::journal::journal article::research article