Baekkeskov, SDyrberg, TLernmark, A2015-12-032015-12-032015-12-03198410.1126/science.6374896https://infoscience.epfl.ch/handle/20.500.14299/121450Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.text::journal::journal article::research article