Pratt, MatthewLashuel, Hilal2024-03-182024-03-182024-03-182024-02-1410.1038/s41589-024-01553-0https://infoscience.epfl.ch/handle/20.500.14299/206392WOS:001162200100001O-linked N-acetylglucosamine (O-GlcNAc) is an endogenous form of glycosylation that alters the structure of alpha-synuclein amyloid fibrils and attenuates their pathogenetic properties. The modified fibrils have a significantly reduced ability to seed the aggregation of endogenous alpha-synuclein in cultured neurons and in mice brains in vivo, which results in reduced pathology.Life Sciences & Biomedicinetext::journal::journal article::research article