Rhodium(III)-Catalyzed Cyclopropane C-H/C-C Activation Sequence Provides Diastereoselective Access to alpha-Alkoxylated gamma-Lactams

Audic, BenoitCramer, Nicolai2020-07-292020-07-292020-07-292020-07-0210.1021/acs.orglett.0c01606https://infoscience.epfl.ch/handle/20.500.14299/170424WOS:000547468700023A Cp*Rh(III)-catalyzed C-H/C-C bond activation sequence of cyclopropyl hydroxamates has been developed. The three-component process allows trapping of the intermediate rhodacycle with diazomalonates and an alcohol nucleophile to provide access to synthetically valuable alpha-alkoxylated gamma-lactams with trans diastereoselectivity.Chemistry, OrganicChemistryh functionalizationintermolecular amidationc(sp(3))-h bondsallylationpalladiumRhodium(III)-Catalyzed Cyclopropane C-H/C-C Activation Sequence Provides Diastereoselective Access to alpha-Alkoxylated gamma-Lactamstext::journal::journal article::research article