Shin, Yong-JunChen, Kai-YuanSayed, Ali H.Hencey, BrandonShen, Xiling2017-12-192017-12-192017-12-19201310.1186/1752-0509-7-83https://infoscience.epfl.ch/handle/20.500.14299/143342The tumor suppressor protein p53 plays important roles in DNA damage repair, cell cycle arrest and apoptosis. Due to its critical functions, the level of p53 is tightly regulated by a negative feedback mechanism to increase its tolerance towards fluctuations and disturbances. Interestingly, the p53 level is controlled by post-translational regulation rather than transcriptional regulation in this feedback mechanism.text::journal::journal article::research article