Durand, HippolyteBaussanne, IsabelleDemeunynck, MartineViger-Gravel, JasmineEmsley, LyndonBardet, MichelZeno, ElisaBelgacem, NaceurBras, Julien2021-05-082021-05-082021-05-082021-06-1510.1016/j.carbpol.2021.117952https://infoscience.epfl.ch/handle/20.500.14299/177954WOS:000639092000007Nowadays, drug encapsulation and drug release from cellulose nanofibrils systems are intense research topics, and commercial grades of cellulose nanomaterials are currently available. In this work we present an ester-containing prodrug of metronidazole that is covalently bound to cellulose nanofibrils in aqueous suspension through a two-step immobilization procedure involving green chemistr y principles. The presence of the drug is confirmed by several characterization tools and methods such as Raman spectroscopy, elemental analysis, Dy-namic Nuclear Polarization enhanced NM R . This technique allow s enhancing the sensitivity of NM R by several orders of magnitude. It has been used to study cellulose nanofibrils substrates and it appears as the ultimate tool to confirm the covalent nature of the binding through thiol-yne click chemistry. Moreover, the ester function of the immobilized prodrug can be cleaved by specific enzyme activity thus allowing controlled drug release.Chemistry, AppliedChemistry, OrganicPolymer ScienceChemistrycellulose nanofibrilsdrug releaseclick chemistrydnp-nmrtext::journal::journal article::research article