Bajard, L.Oates, A. C.2017-05-302017-05-302017-05-30201210.1016/j.cell.2012.03.0242-s2.0-84859776115https://infoscience.epfl.ch/handle/20.500.14299/137758In this issue of Cell, Sparrow et al. propose a new mechanism for sporadically occurring congenital scoliosis in which Notch signaling and hypoxia converge in the embryo on somite patterning via the segmentation clock. This interaction between hypoxia and a predisposed genetic background might underlie other birth defects with incomplete penetrance. © 2012 Elsevier Inc.cell deathembryo pattern formationfibroblast growth factorgene locusgene mutationgenetic predispositiongenotype environment interactiongenotype phenotype correlationhumanhypoxiamesodermnonhumanNotch receptorpenetrancepriority journalReviewscoliosissomitetranscription factortranscription factor HES7transcription factor MESP2unclassified drugWnt proteintext::journal::journal article::research article