Gay, SandrineArostegui, SaioaLemaître, Jacques2010-08-172010-08-172010-08-17200910.1016/j.msec.2008.06.005https://infoscience.epfl.ch/handle/20.500.14299/52228WOS:000262136700027Synthetic bone graft substitutes based on PLLA have been largely studied during the past decade. PLLA/hydroxyapatite composites appear as promising materials for large bone defect healing. In this study dense PLLA/nano-hydroxyapatite composites were prepared by hot pressing. Dense samples were investigated rather than porous scaffolds, in order to shed light on possible correlations between intrinsic mechanical properties and nano-hydroxyapatite concentration. Hydroxyapatite deagglomerated by wet attritionmilling, and further dispersed into chloroform was used (median diameter=80 nm). Particle size distribution measurements and transmission electron microscopy show evidence that particle size and dispersion are maintained throughout the successive steps of composite processing. Mechanical properties were tested (uni-axial and diametral compression tests) as a function of nano-hydroxyapatite content. Increasing concentrations of nano-hydroxyapatite (0, 25 and 50 wt.%) increase the Young's modulus and the mechanical strength of the composite; at the same time, the failure mechanism of the material changes from plastic to brittle. Young's modulus over 6 GPa and uniaxial compressive strength over 100 MPa have been achieved. These values expressed in terms of intrinsic tensile and shear strengths indicate that 50 wt.% nano-hydroxyapatite containing samples develop properties comparable to those of cortical bone. PLLA/nano-hydroxyapatite composites are thus promising candidates to develop bioresorbable porous bone substitutes showing superior mechanical performance.PLLANano-hydroxyapatiteDense compositeBone substituteMechanical propertiestext::journal::journal article::research article