An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I

Bigot, AntonyBois-Choussy, MicheleZhu, Jieping2010-11-252010-11-252010-11-25200010.1016/S0040-4039(00)00695-Xhttps://infoscience.epfl.ch/handle/20.500.14299/58522An efficient synthesis of K-13 (I), a non-competitive inhibitor of ACE I with an endo biaryl ether bond, is described. The key cycloetherification reaction of linear tripeptide II gave a 17-membered macrocycle in quant. yield. [on SciFinder (R)]Peptides Role: SPN (Synthetic preparation)PREP (Preparation) (cyclic; total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I)K13 total synthesis ACE inhibitor; cyclopeptide seventeen member prepn ACE inhibitorAn efficient total synthesis of K-13, a non-competitive inhibitor of ACE Itext::journal::journal article::research article