Papageorgiou, MariaBiver, EmmanuelMareschal, JuliePhillips, Nicholas EdwardHemmer, AlexandraBiolley, EmmaSchwab, NathalieManoogian, Emily N. C.Rodriguez, Elena GonzalezAeberli, DanielHans, DidierPot, CarolinePanda, SatchidanandaRodondi, NicolasFerrari, Serge L.Collet, Tinh-Hai2022-10-242022-10-242022-10-242022-10-1410.1002/oby.23577https://infoscience.epfl.ch/handle/20.500.14299/191624WOS:000867848700001Objective This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health. Methods Adults with >= 1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response. Results In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (>= 0.6 kg weight loss), the bone resorption marker beta-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes. Conclusions TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.Endocrinology & MetabolismNutrition & Dieteticsmineral densityenergy availabilitycaloric restrictionphysical-activityoverweightexerciseadultsobesitywomendiettext::journal::journal article::research article