Delavari, FarnazSandini, CorradoKojovic, NadaSaccaro, Luigi F.Eliez, StephanVan De Ville, DimitriBolton, Thomas A. W.2024-04-172024-04-172024-04-172024-04-0110.1002/hbm.26649https://infoscience.epfl.ch/handle/20.500.14299/207257WOS:001189447100001The temporal variability of the thalamus in functional networks may provide valuable insights into the pathophysiology of schizophrenia. To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro-co-activation patterns (mu CAPs) and employed this method on the human genetic model of schizophrenia 22q11.2 deletion syndrome (22q11.2DS). Participants underwent resting-state functional MRI and a data-driven iterative process resulting in the identification of six whole-brain mu CAPs with specific activity patterns within the thalamus. Unlike conventional methods, mu CAPs extract dynamic spatial patterns that reveal partially overlapping and non-mutually exclusive functional subparts. Thus, the mu CAPs method detects finer foci of activity within the initial seed region, retaining valuable and clinically relevant temporal and spatial information. We found that a mu CAP showing co-activation of the mediodorsal thalamus with brain-wide cortical regions was expressed significantly less frequently in patients with 22q11.2DS, and its occurrence negatively correlated with the severity of positive psychotic symptoms. Additionally, activity within the auditory-visual cortex and their respective geniculate nuclei was expressed in two different mu CAPs. One of these auditory-visual mu CAPs co-activated with salience areas, while the other co-activated with the default mode network (DMN). A significant shift of occurrence from the salience+visuo-auditory-thalamus to the DMN + visuo-auditory-thalamus mu CAP was observed in patients with 22q11.2DS. Thus, our findings support existing research on the gatekeeping role of the thalamus for sensory information in the pathophysiology of psychosis and revisit the evidence of geniculate nuclei hyperconnectivity with the audio-visual cortex in 22q11.2DS in the context of dynamic functional connectivity, seen here as the specific hyper-occurrence of these circuits with the task-negative brain networks.|Unveiling thalamic dynamics in psychosis susceptibility using mu CAPs analysis. Our novel method reveals finer foci of thalamic activity, identifying abnormal connectivity patterns associated with positive psychotic symptoms. Geniculate hyperconnectivity with audio-visual cortex is prevalent during rest in patients, shedding light on thalamic sensory gatekeeping in the pathophysiology of psychosis. imageLife Sciences & Biomedicine22Q11.2 Deletion SyndromeDynamic Functional ConnectivityFunctional ParcelsMicro-Co-Activation PatternsSchizophreniaThalamustext::journal::journal article::research article