Chemoselective ligation methods in TASP design

Tuchscherer, G.Nyanguile, O.Mathieu, M.Nefzi, A.Dumy, P.Kapron, J.Razaname, A.Mutter, M.2006-02-092006-02-092006-02-091995https://infoscience.epfl.ch/handle/20.500.14299/222198A report from a symposium on the prepn. of regioselectively addressable functionalized templates, e.g. cyclo[Lys(AllocNHOCH2CO)-Pro-Gly-Lys(BocNHOCH2CO)-Ala-Lys(SuCH2CH2CO)-Pro-Gly-Lys(FmocNHOCH2CO)-Ala] (Alloc = allyloxycarbonyl, Su = succinimido, Fmoc = 9-fluorenylmethoxycarbonyl), contg. orthogonal protective groups for the selective introduction of peptidyl aldehydes (via oxime linkages) or peptidyl thiols (via addn. to the succinimide group). [on SciFinder (R)]Chemoselective ligation methods in TASP designtext::conference output::conference proceedings::conference paper