Kuhn, R.Schwenk, F.Aguet, M.Rajewsky, K.2007-12-122007-12-122007-12-12199510.1126/science.7660125https://infoscience.epfl.ch/handle/20.500.14299/15457A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase beta gene flanked by IoxP recombinase recognition sites. Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo.text::journal::journal article::research article