Balasubramanian, ViswanathanRuedi, Pierre-FrancoisTemiz, YukselFerretti, AnnaGuiducci, CarlottaEnz, Christian C.2013-12-092013-12-092013-12-09201310.1109/Tbcas.2012.2234121https://infoscience.epfl.ch/handle/20.500.14299/97728WOS:000326622800012This paper presents a novel sensor front-end circuit that addresses the issues of 1/f noise and distortion in a unique way by using canceling techniques. The proposed front-end is a fully differential transimpedance amplifier (TIA) targeted for current mode electrochemical biosensing applications. In this paper, we discuss the architecture of this canceling based front-end and the optimization methods followed for achieving low noise, low distortion performance at minimum current consumption are presented. To validate the employed canceling based front-end, it has been realized in a 0.18 mu m CMOS process and the characterization results are presented. The front-end has also been tested as part of a complete wireless sensing system and the cyclic voltammetry (CV) test results from electrochemical sensors are provided. Overall current consumption in the front-end is 50 mu A while operating on a 1.8 V supply.1/f noisechoppingcurrent mode electrochemical biosensordistortion cancelinglow noiselow powernoise cancelingstrong inversiontransimpedance front-end (read-out)weak inversiontext::journal::journal article::research article