Zhu, JiepingBois-Choussy, MicheleChen, JinchunChen, Xiaochuan2010-11-252010-11-252010-11-252007https://infoscience.epfl.ch/handle/20.500.14299/58423The present invention concerns an intermediate of the following formula I in which R 1 and R 2 represent independently of each other a C 1 -C 12 alkyl group, a (C 1 -C 12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C 2 -C 12 alkenyloxy) carbonyl group, an acyl group, a aryl(C 1 -C 12 )alkyl group, an arylalkoxy carbonyl group, a (C 1 -C 12 alkyl)sulfonyle group or an arylsulfonyl group and R 3 represents a O-protecting group. The present invention concerns also a process of preparation of the intermediate and its use for the preparation of Ecteinascidin 743 and Ecteinascidin-770.Antitumor agents (asym. synthesis of ecteinascidin alkaloidssuch as ecteinascidins 583 and 597)Alkaloids Role: SPN (Synthetic preparation)PREP (Preparation) (asym. synthesis of ecteinascidin alkaloidssuch as ecteinascidins 583 and 597)Stereoselective synthesis (of ecteinascidin alkaloidssuch as ecteinascidins 583 and 597)ecteinascidin alkaloid asym synthesis antitumor agentpatentAT554093EP1937689US8058435US2009171080JP2009512662EP1937689WO2007045686EP1792904WO2007045686CA262659537899253