Wagnieres, GeorgesHadjur, ChristopheGrosjean, PierreBraichotte, DanielSavary, Jean-FrancoisMonnier, PhilippeVan Den Bergh, Hubert2011-02-012011-02-012011-02-01199810.1111/j.1751-1097.1998.tb09696.xhttps://infoscience.epfl.ch/handle/20.500.14299/63761WOS:000075986500025The cutaneous phototoxic reaction induced by i.v. injection of 5,-10,-15,-20-tetra(m-hydroxyphenyl)chlorin (mTHPC) has been clin. evaluated in patients undergoing photodynamic therapy. These tests were performed on the backs of 23 patients with a solar simulator at various times after drug administration ranging from 5 h to 57 days. The mTHPC doses ranged from 0.1 to 0.3 mg/kg, and the illuminations lasted from 30 s up to 8 min. These tests have shown that the duration of the skin photosensitization induced after a typical therapeutic dose of mTHPC (0.15 mg/kg) is less important than with Photofrin? (2 mg/kg). The level of mTHPC in the skin was also assessed in vivo and at times corresponding to the irradiations using an optical fiber-based spectrofluorometer. This study indicates that the light-induced fluorescence spectroscopy of mTHPC enables prediction of the degree of photosensitivity of the skin.122341-38-2 (MTHPC) Role: ADV (Adverse effectincluding toxicity)BIOL (Biological study) (tetra-(m-hydroxyphenyl)chlorin cutaneous phototoxicity)photosensitizer mTHPC tetrahydroxyphenyl chlorin skin phototoxicitytext::journal::journal article::research article