Yue, TaoWang, Mei-XiangWang, De-XianMasson, GeraldineZhu, Jieping2010-11-252010-11-252010-11-25200910.1002/anie.200902385https://infoscience.epfl.ch/handle/20.500.14299/58387That a chiral phosphoric acid is able to catalyze the three-component reaction of aldehydes, anilines, and alpha -isocyanoacetamides, leading to 2-(1-aminoalkyl)-5-aminooxazoles in excellent yields and moderate to good enantioselectivities, was reported. [on SciFinder (R)]Isocyanides Role: RCT (Reactant)RACT (Reactant or reagent) (aminocarbonylmethyl; stereoselective prepn. of 2-(1-aminoalkyl)-5-aminooxazoles via chiral phosphoric acid catalyzed three-component reaction of aldehydesanilinesand alpha -isocyanoacetamides); Amines Role: RCT (Reactant)RACT (Reactant or reagent) (aryl; stereoselective prepn. of 2-(1-aminoalkyl)-5-aminooxazoles via chiral phosphoric acid catalyzed three-component reaction of aldehydesanilinesand alpha -isocyanoacetamides); Bronsted acids Role: CAT (Catalyst use)SPN (Synthetic preparation)PREP (Preparation)USES (Uses) (binaphthalenyl; stereoselective prepn. of 2-(1-aminoalkyl)-5-aminooxazoles via chiral phosphoric acid catalyzed three-component reaction of aldehydesanilinesand alpha -isocyanoacetamides); Heterocyclic compounds Role: SPN (Synthetic preparation)PREP (Preparation) (nitrogen-oxygen; stereoselective prepn. of 2-(1-aminoalkyl)-5-aminooxazoles via chiral phosphoric acid catalyzed three-component reaction of aldehydesanilinesand alpha -isocyanoacetamides); Heterocyclization; Heterocyclization catalysts; Stereoselective synthesis (stereoselective prepn. of 2-(1-aminoalkyl)-5-aminooxazoles via chiral phosphoric acid catalyzed three-component reaction of aldehydesanilinesand alpha -isocyanoacetamides); Aldehydes; Imines Role: RCT (Reactant)RACT (Reactant or reagent) (stereoselective prepn. of 2-(1-aminoalkyl)-5-aminooxazoles via chiral phosphoric acid catalyzed three-component reaction of aldehydesanilinesand alpha -isocyanoacetamides); Multicomponent reaction (three-component; stereoselective prepn. of 2-(1-aminoalkyl)-5-aminooxazoles via chiral phosphoric acid catalyzed three-component reaction of aldehydesanilinesand alpha -isocyanoacetamides); Amides Role: RCT (Reactant)RACT (Reactant or reagent) (alpha -isocyano; stereoselective prepn. of 2-(1-aminoalkyl)-5-aminooxazoles via chiral phosphoric acid catalyzed three-component reaction of aldehydesanilinesand alpha -isocyanoacetamides)aldehyde aniline isocyanoacetamide imine chiral phosphoric acid enantioselective heterocyclization; aminoalkyl aminooxazole stereoselective prepn; enantioselective three component heterocyclization catalyst chiral phosphoric acidBronsted Acid Catalyzed Enantioselective Three-Component Reaction Involving the alpha Addition of Isocyanides to Iminestext::journal::journal article::research article