Jenke, M.G.Schreiter, C.Kim, G.M.Vogel, H.Brugger, J.2007-09-142007-09-14200710.1007/s10404-006-0119-2https://infoscience.epfl.ch/handle/20.500.14299/12119WOS:000244400700007We describe the fabrication and application of a bioanalytical chip, made of SU-8 photoresist, comprising integrated, high aspect-ratio microfluidic channels, suitable to manipulate and investigate vesicles, cell fragments and biological cells. A central micrometer-sized aperture allows electrical particle counting and planar membrane experiments, microfluids allow (sub)micrometer-sized objects to be transported and addressed with different chemicals. Here we show how lipid vesicles are positioned with micrometer precision within the micro-channels by means of pressure and electrophoretic movement. Our approach is suited for controlling and investigating (bio)chemical synthesis and cellular signalling processes in ultrasmall individual vesicles by electro-optical techniques.text::journal::journal article::research article