Piou, TiffanyNeuville, LucZhu, Jieping2012-08-232012-08-232012-08-23201210.1021/ol301616whttps://infoscience.epfl.ch/handle/20.500.14299/85039WOS:000306536500050Treatment of a DMA solution of anilide 1 with a catalytic amount of palladium acetate (0.025 equiv) and XPhos (0.05 equiv) in the presence of potassium carbonate (2.0 equiv) at 100 C afforded dihydroquinolin-2-ones spiro-fused to dihydrofuranyl, indolinyl, and indanyl 2 in good to excellent yields. The reaction went through a domino sequence involving a 5-exo-trig Heck cyclization followed by an intramolecular direct CH functionalization.Quaternary Carbon CentersAsymmetric-SynthesisAryl ChloridesNatural-ProductsBond FormationOxindolesFunctionalizationConstructionActivationSpirooxindolesSpirocyclization by Palladium-Catalyzed Domino Heck–Direct C–H Arylation Reactions: Synthesis of Spirodihydroquinolin-2-onestext::journal::journal article::research article