Ramirez, Nieves P.Pisella, GuillaumeWaser, Jerome2021-08-282021-08-282021-08-282021-08-0610.1021/acs.joc.1c01423https://infoscience.epfl.ch/handle/20.500.14299/180857WOS:000684025500086The gem-aminoalkynylation of fluorinated diazo compounds catalyzed by a simple Cu(I) salt is described. This three-component reaction allows the synthesis of propargylic amines with broad functional group tolerance. Both electron-rich and electron-poor anilines can be used as nucleophiles and alkyl-, aryl-, and silyl-substituted EthynylBenziodoXoles (EBX) as electrophiles.Chemistry, OrganicChemistrycatalyzed oxy-alkynylationasymmetric-synthesisenantioselective synthesis3-component reactionacidtrifluorodiazoethaneisocyanidesreductionketiminesreagentsCu(I)-Catalyzed gem-Aminoalkynylation of Diazo Compounds: Synthesis of Fluorinated Propargylic Aminestext::journal::journal article::research article