Roshan Ghias, AlirezaTerrier, AlexandreJolles-Haeberli, BrigittePioletti, Dominique2012-08-062012-08-062012-08-06201410.1080/10255842.2012.719607https://infoscience.epfl.ch/handle/20.500.14299/84448WOS:000334075400004Bone defects in revision knee arthroplasty (RKA) are often located in load-bearing regions. The goal of this study was to determine if a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to answer this question, we proposed a novel translation procedure having four steps: 1) Determining the mechanical stimulus using FEM, 2) Designing an animal study to measure bone formation spatially and temporally using micro-CT imaging in the scaffold subjected to the estimated mechanical stimulus, 3) Identifying bone formation parameters for the loaded and non-loaded cases appearing in a recently developed mathematical model for bone formation in scaffold, and 4) Estimation of stiffness and the bone formation in the bone-scaffold construct. With this procedure, we estimated that after three years mechanical stimulation increases the bone volume fraction and the stiffness of scaffold by 1.5-fold, and 2.7-fold, respectively.bone scaffoldtotal knee implant revisionmechanical loadingin vivofinite element methodtranslational medicinetext::journal::journal article::research article