Frei, RetoStädler, DavideRaja, ArunaFranke, RaimoSasse, FlorenzGerber-Lemaire, SandrineWaser, Jérôme2013-10-222013-10-222013-10-22201310.1002/anie.201305533https://infoscience.epfl.ch/handle/20.500.14299/96324WOS:000327802100046The first total synthesis of the alkaloid natural product jerantinine E is based on a selective cyclization of an aminocyclopropane. Preliminary investigations show that it inhibits the polymerization of tubulin, displaying significant cytotoxicity and antimigratory activity against both breast and lung cancer cell lines.alkaloidscancerindolesnatural productstotal synthesistext::journal::journal article::research article