Ye, BaihuaDonets, Pavel A.Cramer, Nicolai2014-02-172014-02-172014-02-17201410.1002/anie.201309207https://infoscience.epfl.ch/handle/20.500.14299/100722WOS:000329152600027Metal-catalyzed functionalizations at the ortho position of a directing group have become an efficient bond-forming strategy. A wide range of transformations that employ Cp*Rh-III catalysts have been described, but despite their synthetic potential, enantioselective variants that use chiral versions of the Cp* ligand remain scarce (Cp*=pentamethyl cyclopentadienyl). Cyclopentadienyl compounds with an atropchiral biaryl backbone are shown to be suitable ligands for the efficient intramolecular enantioselective hydroarylation of aryl hydroxamates. Dihydrofurans that bear methyl-substituted quaternary stereocenters are thus obtained by CH functionalization under mild conditions.asymmetric catalysisCH activationcyclopentadienyl ligandshydroarylationrhodiumtext::journal::journal article::research article