Highly enantioselective inverse-electron-demand hetero-Diels-Alder reactions of α,β-unsaturated aldehydes

Gademann, KarlChavez, David E.Jacobsen, Eric N.2006-11-222006-11-22200210.1002/1521-3773(20020816)41:16<3059::AID-ANIE3059>3.0.CO;2-Ihttps://infoscience.epfl.ch/handle/20.500.14299/235829Simple, α,β-unsaturated aldehydes are excellent substrates in the hetero-Diels-Alder reaction with inverse electron demand, catalyzed by the Cr(III)-Schiff base complex I in the presence of 4-Ǻ molecular sieves and without solvent. The resulting dihydropyrans are obtained with high enantio- (89-98% ee) and diastereoselectivity (> 95% de) and in good yields (40-95%).asymmetric catalysischromiumcycloadditiondihydropyranhetero-Diels-AlderHighly enantioselective inverse-electron-demand hetero-Diels-Alder reactions of α,β-unsaturated aldehydestext::journal::journal article::research article