Wu, HuaWang, QianZhu, Jieping2017-10-282017-10-282017-10-28201710.1002/chem.201703563https://infoscience.epfl.ch/handle/20.500.14299/141680A copper-catalyzed enantioselective arylative semipinacol rearrangement of allylic alcohols was developed. In the presence of a catalytic amount of an in situ generated chiral copper-bisoxazoline complex, reaction of allylic alcohols with diaryliodonium salts afforded spirocycloalkanones in high yields with high diastereo- and enantioselectivities. A two-point binding model engaging the carbon–carbon double bond and the proximal hydroxyl group was proposed to be responsible for the highly efficient chirality transfer.asymmetric catalysisdiaryliodonium salthomogeneous catalystring expansionsemipinacol rearrangementtext::journal::journal article::research article