Timmers, SilvieAuwerx, JohanSchrauwen, Patrick2012-05-182012-05-182012-05-18201210.18632/aging.100445https://infoscience.epfl.ch/handle/20.500.14299/80600WOS:000303240500002The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.ResveratrolSirt1sirtuinscalorie restrictionagingmetabolic diseasesActivated Protein-KinaseModerate Wine ConsumptionLife-SpanTrans-ResveratrolCaloric RestrictionLiquid-ChromatographyInsulin SensitivityHealthy-VolunteersSirt1 ActivationClinical-Trialstext::journal::journal article::review article