Geraschenko, Oleksandr V.Solomin, Vitalii V.Vashchenko, Bohdan V.Khodakivskyi, PavloTolmachev, Andrey A.Grygorenko, Oleksandr O.2020-03-032020-03-032020-03-032020-01-0110.1016/j.jfluchem.2019.109407https://infoscience.epfl.ch/handle/20.500.14299/166721WOS:000509631900009Optimized protocols for the synthesis of diazolyl alpha,alpha-difluoroacetates via deoxofluorination of the corresponding glyoxylates with Morph-DAST are described. The method allowed the preparation of the title fluoridated building blocks in 73-96 % yield on up to 15 g scale. Utility of the hetaryl alpha,alpha-difluoroacetates was demonstrated by the synthesis of advanced building blocks for medicinal chemistry, i.e. carboxylic acids, amides, nitriles, and alcohols.Chemistry, Inorganic & NuclearChemistry, OrganicChemistrydeoxofluorinationnitrogen heterocyclesgem-difluorinated compoundsbuilding blocksazolesasymmetric-synthesistrifluorideacidsfluorinationconvenientdiscoveryoptimizationderivativesinhibitorsbearingtext::journal::journal article::research article