Bobbio, CarlaSchlosser, Manfred2006-03-032006-03-032006-03-03200510.1021/jo047979hhttps://infoscience.epfl.ch/handle/20.500.14299/227041WOS:0002283671000166533The concept of "regioexhaustive substitution" has been successfully applied to 2-fluoro-, 2,3-difluoro-, and 2,5-difluoropyridine. All vacant positions were amenable to regioselective metalation and subsequent carboxylation by employing either chlorine as a neighboring site activating protective group or trimethylsilyl as a neighboring site screening protective group. In this way, approx. half a dozen fluorinated pyridinecarboxylic acids were derived from each starting material. [on SciFinder (R)]Protective groups (regioselective metalation and subsequent carboxylation of fluoropyridines by employing either chlorine as a neighboring site activating protective group or trimethylsilyl as a neighboring site screening protective group); Metalation (fluoropyridine regioselective metalation carboxylation; pyridinecarboxylic acid fluoro prepntext::journal::journal article::research article