Enhanced and Enduring Protection against Tuberculosis by Recombinant BCG-Ag85C and Its Association with Modulation of Cytokine Profile in Lung

Jain, RuchiDey, BappadityaDhar, NeerajRao, VivekSingh, RamandeepGupta, Umesh D.Katoch, V. M.Ramanathan, V. D.Tyagi, Anil K.2010-11-302010-11-302010-11-30200810.1371/journal.pone.0003869https://infoscience.epfl.ch/handle/20.500.14299/60594WOS:000265452200013Background: The variable efficacy (0-80%) of Mycobacterium bovis Bacille Calmette Gurein (BCG) vaccine against adult tuberculosis (TB) necessitates development of alternative vaccine candidates. Development of recombinant BCG (rBCG) over-expressing promising immunodominant antigens of M. tuberculosis represents one of the potential approaches for the development of vaccines against TB.Enhanced and Enduring Protection against Tuberculosis by Recombinant BCG-Ag85C and Its Association with Modulation of Cytokine Profile in Lungtext::journal::journal article::research article