École Polytechnique Fédérale de Lausanne (EPFL)Liu, BaohongLiang, QiaoJovic, MilicaZhu, YingdiPick, HorstGirault, Hubert2019-12-052019-12-052019-12-052018-07-28https://infoscience.epfl.ch/handle/20.500.14299/163744A target plate for enhanced matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) analysis of intact biological entities. The target plate comprises an electrically conductive substrate (1) covered at least partially with immobilised photo-reactive nanoparticles (2), acting as a photosensitizer and an ionization device, which drives efficient electron-transfer and radical reactions causing in-source disruption of the envelope structure of intact biological entities (3) and helps in desorption/ionization of components such as lipids, peptides and proteins from the intact biological entities to the MS analyser.patentWO2018134232GB20170090858462970