Tong, ShuoPiemontesi, CyrilWang, QianWang, Mei-XiangZhu, Jieping2017-06-282017-06-282017-06-28201710.1002/anie.201704727https://infoscience.epfl.ch/handle/20.500.14299/138638WOS:000403839000050The reaction of secondary homopropargylamines, isocyanides, and water in the presence of a catalytic amount of silver acetate and subsequent purification by chromatography on silica gel afforded substituted proline amides in good to excellent yields. Primary homopropargylamines underwent a cyclizative Ugi -Joullié three-component reaction with isocyanides and carboxylic acids to afford functionalized N-acyl proline amides. High diastereoselectivity was observed in the synthesis of 4-alkoxy and 4,5-disubstituted proline derivatives. This work represents the first examples of a three-component cyclizative 1,1-aminoacylation of terminal alkynes.alkynesheterocyclesisocyanidesmulticomponent reactionssilvertext::journal::journal article::research article