Qiao, LiangTobolkina, ElenaLesch, AndreasBondarenko, AlexandraZhong, XiaoqinLiu, BaohongPick, Horst MatthiasVogel, HorstGirault, Hubert H.2014-01-222014-01-222014-01-22201410.1021/ac4031779https://infoscience.epfl.ch/handle/20.500.14299/100118WOS:000331775600017Imaging samples on a surface by mass spectrometry (MS) requires the combination of MS detection with a scanning mode that enables localized desorption and ionization and/or detection of sample analytes with good spatial resolution. We have developed a new mass spectrometry imaging (MSI) method based on electrostatic spray ionization. It works under ambient conditions and can be applied to a wide range of molecules providing quantitative MS analysis even in the presence of salts in excess. 2D MS images of protein and peptide spots, inkjet-printed black dye patterns, and cells were obtained. The presented novel ambient ionization mass spectrometry imaging method can find many applications in analytical and bioanalytical chemistrytext::journal::journal article::research article