Bifari, FrancescoDecimo, IlariaPino, AnnachiaraLlorens-Bobadilla, EnricZhao, ShengLange, ChristianPanuccio, GabriellaBoeckx, BramThienpont, BernardVinckier, StefanWyns, SabineBouche, AnnLambrechts, DietherGiugliano, MicheleDewerchin, MiekeMartin-Villalba, AnaCarmeliet, Peter2017-03-272017-03-272017-03-27201710.1016/j.stem.2016.10.020https://infoscience.epfl.ch/handle/20.500.14299/135841WOS:000396375300011Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and differentiate into Satb2(+) neurons in cortical layers II-IV. The resulting neurons are electrically functional and integrated into local microcircuits. Single-cell RNA sequencing identified meningeal cells with distinct transcriptome signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural stem cells in the SVZ), (2) neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial glia-like meningeal cells differentiating to neuronal cells. Thus, we have identified a pool of embryonically derived radial glia-like cells present in the meninges that migrate and differentiate into functional neurons in the neonatal cerebral cortex.text::journal::journal article::research article