Vandersarl, Jules J.Renaud, Philippe2016-10-072016-10-07201610.1038/srep32485https://infoscience.epfl.ch/handle/20.500.14299/129675WOS:000382246200002Here we present a planar patch clamp chip based on biomimetic cell membrane fusion. This architecture uses nanometer length-scale surface patterning to replicate the structure and function of membrane proteins, creating a gigaohm seal between the cell and a planar electrode array. The seal is generated passively during cell spreading, without the application of a vacuum to the cell surface. This interface can enable cell-attached and whole-cell recordings that are stable to 72 hours, and generates no visible damage to the cell. The electrodes can be very small (<5 μm) and closely packed, offering a high density platform for cellular measurement.text::journal::journal article::research article